The research introduces the concept of smart cruise destination in order to manage in an innovative way the cruise tourist flows. The network of cruise destination is based on the principle of sustainable tourism. It considers a framework consisting of a combination of distributed knowledge, data and models. Through this framework, the stakeholders have the possibility to base on sound and rational bases all decisions concerning policies, infrastructure development and the managing system. Moreover, the smart cruise destination is based on the evolution of the well-known tourism destination concepts with the aim to enhance both the residents’ wellbeing and tourists’ enjoyment and satisfaction. To fulfil this aim, the knowhow of experience economy is adopted in different scale.